Ad Secondary Development prompts "An operation error occurred" SOLUTION

Recently VS solution operates on ad. I can run it in vs (completely normal, data can be read ). However, the following error occurs after I publish the website to IIS separately:

Why can't debugging be solved? Later, I guess this is a permission issue. You run normally in Vs because the Running Account of VS has the corresponding permissions. However, IIS does not have the required permissions. Check the web application.ProgramWhat is the account of the corresponding application pool in IIS and whether it has the permission to access the domain.

So the account used to open the application pool running on the site is applicationpoolidentity, Which is changed to a domain account with access permissions. Here we changed it to contoso \ administrator.

After the change, the system runs normally as follows: