Failure phenomena
Install well when you sign in to OWA after Exchange, you are prompted with "Outlook Web App is not initialized." If the problem persists, contact your technical support staff. The Microsoft Exchange Active Directory topology service on Serverlocalhost do not return any suitable domain controllers . "error.
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Cause of failure
This failure occurs because The reason that the related authentication method is not enabled on the Exchange server for IIS.
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Workaround
Open On the Exchange server, on the IIS management interface, select OWA under the default Web sitesite inIIS, double-click Authentication, Select the authentication method that you want to enable for enable. For example, the Windows authentication method needs to be enabled in this example .
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This article from "The Light of Asia" blog, declined reprint!
Exchange2010 OutLook Web app is not initialized