The solution is simple:
1. In the control panel, uninstall the program and uninstall nuget;
2. If you are using a Windows 7 system, run vs with the Administrator permission (otherwise the nuget unmount button is unavailable). You can still see nuget in the tool-Extension Manager., Unmount nuget again;
3. Install the latest version of nuget directly in the Extension Manager.
The original official solution is as follows:
Upgrading to latest nuget from an older version causes a signature verification error.
If you are running vs 2010 SP1, you might run into the following error message when attempting to upgrade nuget if you have an older version installed.
When viewing the logs, you might see a mention of a signaturemismatchexception.
The workaround is to simply uninstall nuget and then install it from the vs extension Gallery.
See http://support.microsoft.com/kb/2581019 for more information.