Zinc gluconate (also known as Zincum Gluconicum)

Zinc gluconate (also called zincum gluconicum) is the zinc salt of gluconic acid. It is an ionic compound consisting of the moles of gluconate for each mole of zinc. Zinc gluconate is a popular form for the delivery of Zinc as a dietary supplement.

Gluconic acid is found naturally, and was industrially manufactured by the fermentation of glucose, typically by Asperg Illus Niger, but also by other fungi, e.g. Penicillium, or by bacteria, e.g. acetobacter, pseud Omonas and gluconobacter. ^{[1] in its pure form, it's a white to off-white powder. It can also be manufactured by electrolytic oxidation,[2] Although the is a more expensive process. The advantages is a lower microbiological profile, and a more complete reaction, yielding a product with a longer shelf l Ife.}

Contents

• 1 Zinc gluconate and the common cold
• 2 Safety concerns
• 3 See also
• 4 References
• 5 External Links

Zinc gluconate and the common cold

Zinc gluconate has been used on lozenges for treating the common cold. However, controlled trials with lozenges composed of zinc acetate has found the greatest effect on the duration of colds. ^[3][4][5]

Zinc have also been administered nasally for treating the common cold, but anosmia have been claimed to being caused by such TR Eatment (see below).

Safety Concerns

Instances of anosmia (loss of smell) has been reported with intranasal use of some products containing zinc gluconate. In September 2003, Zicam faced lawsuits from users who claimed the product, a nasal gel containing zinc gluconate an D Several inactive ingredients, negatively affected their sense of smell and sometimes taste. Some plaintiffs alleged experiencing a strong and very painful burning sensation when they used the product. Matrixx Initiatives, Inc., the maker of Zicam, responded that is only a small number of people had experienced problems and t Hat anosmia can caused by the common cold itself. In January 2006, 340 lawsuits were settled for million. ^[6]

The U.S. Food and Drug Administration (FDA) considers zinc gluconate to being generally recognized as safe (GRAS) when used I n accordance with good manufacturing practice, although this does no constitute a finding by the FDA that the substance I s a useful dietary supplement.^{[7] on June, the FDA "warned consumers to stop using and discard three zinc-containing Zicam intranasal product S. The cause a loss of sense of smell. ... FDA is concerned, that the loss of sense of smell are permanent. " [8][9] Matrixx responded that the FDA ' s allegations were "unfounded and misleading", citing a lack of evidence fro M controlled tests that Zicam causes anosmia. [ten] in its warning, the FDA stated, "This warning does not involve oral zinc tablets and lozenges taken by mouth. Dietary zinc is also not subject to this warning. " [8]}

See also

• Neutersol, a veterinary chemical castration drug containing Zinc gluconate

Zinc gluconate (also known as Zincum Gluconicum)