Problem: Some software when reading the user's desktop address from the registry, the%userprofile% situation, such as Thunderbolt when opening the file, will prompt:
[Window Title]
Location not available
[Content]
C:\WINDOWS\system32\config\systemprofile\Desktop is not available. If the location is on this computer, make sure that the device or drive is connected, or that the disc is plugged in, and then try again. If the location is on a network, make sure that you are connected to the network or the Internet, and then try again. If the location is still not found, it may have been moved or deleted.
Determine
Solve:
Change two registry key values to: C:\users\[current user Name]\desktop
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\Shell Folders\desktop
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders\desktop
20160803-c:\windows\system32\config\systemprofile\desktop not available to resolve