C-reactive protein

C-reactive protein ( English:c-reactive Protein,CRP) is a plasma protein produced by the liver and is mainly used as an indicator of inflammation . Loinc Terminology Standard for the definition and coding of serum/plasma CRP test items, see here.

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• 1 Introduction
• 2 Diagnostic Value
• 3 History
• 4 new indicators of cardiovascular disease

Introduction

C-reactive protein consists of five 24,000 Dalton (including 206 amino acids) with non-covalent link to a five-body ring structure. C-reactive protein binds to the dead cell or microbial extracellular membrane of choline phosphate (phosphocholine) to activate the complement system. When the body has acute inflammation, bacterial infection, tissue damage, C-reactive protein appears within a few hours, and the disease is cured and soon disappears.

Diagnostic Value

C-reactive protein does not apply to the diagnosis of a single disease. Its clinical value is mainly in the screening and monitoring of tissue damage, and is used to evaluate the effectiveness of anti-inflammatory medications by determining whether the patient is inflamed and diagnosing the likelihood of a relapse of an inflammatory disease. In addition C-reactive protein can be used to assist in the diagnosis of rheumatoid arthritis .

history

It was discovered by Tillett and Francis in 1930 that the C-reactive protein was named because of its precipitating reaction to the c-polysaccharide of Streptococcus pneumoniae.

new indicators of cardiovascular disease

Since 1997, Paul M. Ridker, a cardiologist at the Duma Women's Hospital in the United States, has noted that a molecular C-reactive protein associated with inflammation (c-reactive protein, CRP) is associated with heart disease. Recent studies have found that C-reactive protein is a risk factor for cardiovascular diseases , including coronary heart disease.

C-reactive protein