Extracellular matrix (extracellular matrix)

The biological, extracellular , or extracellular matrix (extracellular matrix,ecm) is part of an animal tissue and does not belong to any cell. The extracellular mass determines the characteristics of connective tissue.

Directory

• 1 Composition
• 2 features
• 3 cell adhesion
• 4 Diseases
• 5 References
• 6 External Links

constituent Components

• Fiber structure Protein: collagen, elastin, laminin and fibronectin. One of the most important ingredients is collagen. These proteins are giant macromolecules that form a tough three-strand spiral structure.
• Polysaccharide: Hyaluronic Acid (Hyaluronan).
• Proteoglycan: chondroitin sulfate (chondroitin) containing glucosamine, hyaluronic acid (hyaluronic), glycoprotein containing heparin sulfate.

In addition, the extracellular mass also absorbs a variety of cell growth factors and proteases. When physiological conditions change, the protease is activated to release these cytokines without having to synthesize these factors from scratch, thus activating the cellular function quickly.

function

In view of the diversity of extracellular mass, extracellular mass has many functions. For example, providing support and fixation for cells, providing separation between tissues, and regulating intercellular communication. Extracellular mass regulates the dynamic behavior of cells.

cell adhesion

Many cells are combined with the extracellular substance of the cell. This cell-to-cell adhesion is regulated by specific cell surface cell adhesion molecules such as adhesive (integrin). The adhesive can conduct mechanical stimulation from the extracellular mass to the cytoskeleton.

disease

Extracellular mass in tumors ^{[1], fibrosis [2], wound healing [2], inflammatory reaction [3]}

Extracellular matrix (extracellular matrix)