Hya.io is a web -based audio application that supports hardware MIDI through Web midi, audio synthesizer, sequencer and a number of plugins. You can add plugins to the workspace, connect them to routed audio, play them, and experiment.
The HYA supports AMD and ES6 modules. They use a simple JSON object to describe the plug-in and a constructor. You can use various events, such as Handlemouseover and Handlemousedown, to bind to the Hya GUI.
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