Why does "excellent card Dan" become a child "cautious use" cold medicine?

You and the doll. These two compound children's cold medicine, the main ingredient of acetaminophen in the long-term, a large number of applications may have a certain impact on the liver and kidney. Figure IC recently, certified as a pediatrician of the Netizen, said, "excellent card Dan and the child of ammonia-phenol amine granules, has been fully proved to children's liver and kidney toxicity, a year old within the ban, six-year-old cautious clothing." According to the state Food and Drug Administration's May 17, 2012 notice, the reason for children under 1 years of age to ban acetaminophen is not "liver and kidney toxicity" but because of "lack of evidence of safety and efficacy of newborns and infants under one year of age", the official statement said. "1-12-Year-old children according to the instructions can be assured to use, will not cause damage to liver and kidney function." "Gifted Cardin, good dolls and other child ammonia phenol amine granule whether to have kidney toxicity?" "After access to relevant information, both excellent and good dolls are compound formulations, containing the same composition and content of the same." Wang Xiangyan, a clinical pharmacist in the pharmacy of the Capital Institute, said, "the specific ingredients and content are: 0.1 grams of acetaminophen, 0.04 grams of amantadine hydrochloride, artificial Bezoar 4 mg, caffeine 6 mg, maleic acid chlorobenzene 0.8 mg." "" Through the composition analysis, you can understand that in the combination of the two compound children's cold medicine, the main acetaminophen in the long-term, a large number of applications may have a certain impact on the liver, kidney, other components of the liver, kidney impact is not obvious. Wang Xiangyan said, in addition to the new pharmacy (version 17), it is clear that amantadine hydrochloride is not used in newborns and infants aged 1 years. 3 other ingredients in the "New Pharmacy" (17 edition) or "Martindale Medicine" (35 edition) have 1 years of age in the use of children. "Of course, excellent card Dan and good dolls as a compound preparation, when several ingredients are taken together, there is the problem of drug interaction, may produce the above several ingredients alone without pharmacological action or adverse reaction, which requires drug manufacturers to carry out adequate clinical research." "Hospital conditions for children's hospitals, Children's Institute do not need to be gifted," according to the Beijing Children's Hospital, the capital of the Institute of Pediatrics did not use excellent card Dan and good dolls these two drugs. Beijing Children's Hospital responsible person explained, "The General Doctor is commonly used in hospital medicine, specifically whether to use to see a doctor's own medication habits, can not represent the entire medical profession opinion." The key to this problem is the revision of the specification. "National Ministry of Health, the National rational drug Monitoring system experts, China's Over-the-counter drug association expert Sun Zhongxi said last May, the FDA issued a request for manufacturers to revise the instructions, the general will give six months to modify. "To the present manual has not been changed to children under 1 years of age disabled, children under 5 years of age are not recommended, is the manufacturer's error." "Security discussion a variety of pediatric cold drugs are included in the amantadine," said Kiang Lianmei, a senior pharmacist at the hospital, the varieties containing amantadine include the children's ammonia-phenol-amine granules in sunflower, ren-he-pharmaceutical (children's ammonia-phenol-amine granule), the Asia-pharmaceutical quick-gram capsules (compound paracetamol and amantadine amine capsules), and the Sun Stone Medicine's Good dolls ( Ammonia in childrenPhenol Amine granule), etc., not only the children of ammonia-phenol-amine particles containing amantadine, some other children's cold medicine also contains, if the parents will be two kinds of cold medicine containing amantadine to children to take, there is the possibility of kidney toxicity, because amantadine mainly through the kidney excretion. However, so far, there is no such adverse reaction monitoring data at home and abroad. Disabling and cautious use is due to the safety of medication for children Sun Zhongxi says the state administration of medicine issued last May, "on the revision of the non-prescription drug containing amantadine hydrochloride instructions," It does only write "in the" taboo "to increase the lack of newborn and infants under 1 years of age safety and efficacy of data, newborn and 1 years old children under the prohibition of this product , the announcement also called for amendments to the "paracetamol and amantadine-sensitive capsules" manual, "children under 5 years of age should be used under the guidance of physicians" revision to "children under the age of 5 not recommended", but did not involve adverse drug reactions information. "Because the ethical rules for drug testing do not give children clinical trials. The effects of liver and kidney function are not clear. Disabling and careful use are all motivated by the safety of medication for children. "However, in the recommended dosage range, most people are safe." Any drug has both advantages and disadvantages, and no one is absolutely safe. Amantadine against cold virus Kiang Lianmei said, foreign evidence-based medicine research has shown that amantadine in the anti-cold virus is basically ineffective, cold virus against its serious drug resistance. "Amantadine is an antiviral ingredient in cold medicine approved by the National Drug Administration, which has been in clinical practice." Sun Zhongxi said, "but amantadine only against influenza A virus, is a narrow spectrum of antiviral drugs, cold virus has many kinds of, in practice, the effect of amantadine in anti-virus is Da Guo." There is no more reason to overturn the prescription now. In addition, the advertisement says that it can ' prevent ', ' treat ' a cold, namely in the cold epidemic period can advance one or two weeks to eat to prevent. But in fact, the medical profession recognized that can prevent the influenza virus is Roche's Duffy, other does not have the related evidence. Therefore, the prevention of colds is also to Da Guo. "Sun Zhongxi said. Hot Quiz Children cold medicine is not adult shrink version Q adult Cold medicine also contains acetaminophen and amantadine compound composition, is not understandable for the children of cold medicine is the adult cold medicine shrink version? Wang Xiangyan: The common cold medicine in adults, pseudoephedrine hydrochloride and the right U.S. Dextromethorphan are commonly used in children's cold medicine is not the ingredients, mainly used in adult town cough. Whether it is adults or children of cold drugs are compound preparations, but the two contain specific ingredients or there is a certain difference, can not simply think of children cold medicine is the reduction of adult cold medicine version. Sun Zhongxi: The active ingredient of the adult cold medicine and the child cold medicine is similar, for example, acetaminophen is used for antipyretic analgesia, chlorobenzene-sensitive, benzene-dextromethorphan plays an allergic role, right-American is used to relieve cough, pseudoephedrine is used to reduce the congestion, and amantadine can act as an antiviral. The vasoactive constituents of pseudoephedrine are not used in children, and other components can beFor adults or children with cold medicine. The average doctor calculates the dosage and design prescriptions based on the weight and age of the child, instead of simply halving it as appropriate. Q What is the situation of foreign children using cold medicine? Sun Zhongxi: The United States in the FDA2006 year under 2 years old not to use anti-cold medicine, but the use of non-drug therapy, through more water, to ensure ventilation, if necessary, to carry out cold water bath and alcohol bath heat dissipation. Only 38.5 degrees of fever can be used for a small amount of acetaminophen. This edition/Beijing News reporter Pumblechook