Anti-RA33 antibody

1989 Hassfeld, such as the first reported RA33 antibody, because the antibody is the diagnosis of RA (rheumatoid arthritis) more specific antibodies, but also with molecular weight of 33KD nucleic acid protein reaction, so named anti-RA33 antibody. Its target antigen is 33KD nucleic acid binding protein, which is consistent with A2 protein in HNRNP, and the antigen is derived from Hela cells or ehrilich cells. The method of detection is Western blot (IBT). 1992 Hassfeld in the detection of anti-RA33 antibodies at the same time, found that some RA patients with a 36KD nucleic acid protein antibody, and the latter and the antigen molecular weight of 36KD of the anti-proliferating cell nuclear antigen antibody (anti-PCNA antibody) independent. Anti-RA33 antibody and anti-RA36 antibody often appear at the same time, in western blot detection, such as the presence of 33KD, 36KD at the same time to form two characteristic bands, the diagnosis of RA is specific. In the early diagnostic indicators of RA, the anti-RA33 antibody was the most specific, with a positive rate of 35.8% in RA, especially in early RA. The growth and decline of anti-RA33 antibody was unrelated to the disease and medication.

Anti-RA33 antibody