Magnesium glycyrrhizinate is a kind of medicine, which is commonly known as ISO-Glycyrrhizic acid magnesium injection. The magnesium glycyrrhizinate injection is a colorless clear liquid, the main ingredient is the isoflavones magnesium, its chemical name is: 18α,20β-carboxyl -11-oxygen Generation N- -12- -3β--based -2-o-β-d-grape glucoside aldehyde acid base D grape glucoside aldehyde acid magnesium four hydrate. It is suitable for chronic viral hepatitis and improves liver function abnormality.
name of drugCommon name: Glycyrrhizic acid Magnesium Injection product Name: Sunny sweet Hanyu Pinyin: Yigancaosuanmei Zhusheye The main ingredient of this product is ISO-Glycyrrhizic acid magnesium, its chemical name is: 18α, 20β-carboxyl -11-Oxygen Generation N- -12- -3β--based -2-o-β-d-grape glucoside aldehyde acid base D grape glucoside acid magnesium four hydrate. Its structure is shown in the figure on the right.iso-Glycyrrhizic acid-magnesium structure-for Baidu Encyclopedia draw [1]Molecular formula: C42H60MGO16
·4H2O Molecular Weight: 917.28TraitsThis product is colorless clear liquid.Pharmacological Toxicology
Pharmacological ActionMagnesium Glycyrrhizic acid is a kind of hepatocyte protective agent, which has the function of anti-inflammation, protecting liver cell membrane and improving liver function. The effect of magnesium glycyrrhizinate on the acute hepatic injury induced by D-Amino galactose in rats was demonstrated,LicoriceIt can prevent the increase of serum transaminase and reduce the infiltration of hepatocyte degeneration, necrosis and inflammatory cells, which has therapeutic effect on chronic hepatic injury induced by carbon tetrachloride, improves liver function in rats with chronic liver injury induced by CCL4, reduces the level of no, and relieves inflammatory activity and fibrosis degree of liver tissue. gal/ The FCA induced immune liver damage in mice also had protective effect, decreased serum transaminase and plasma no level, reduced liver tissue damage and improved survival rate of mice.Toxicological StudiesGenetic toxicity: This product Ames bacterial recovery mutation test, the Chinese hamster lung fibroblast chromosome aberration test and the mice Micronucleus test results are negative. Reproductive toxicity: The effect of magnesium glycyrrhizic acid on SD rats was obviously teratogenic. The non-toxic reaction dose of the rat general reproductive toxicity test was 40mg/kg, which was equivalent to 3 times times the clinical recommended dosage, which was converted by body surface area. SD female rats in the end of pregnancy and the lactation period to give a larger dose of different magnesium glycyrrhizinate, non-toxic reaction dose of 40mg/kg, according to the body surface area, about the equivalent of 3 times times the clinical recommended dosage. "Precautions" 1. In the course of treatment, blood pressure and serum potassium and sodium concentrations should be measured regularly. 2, this product may cause the increase of false aldosterone, in the course of treatment such as fever, rash, hypertension, blood sodium retention, low potassium blood, etc., should be discontinued. "The use of drugs for pregnant and lactating women" is not currently available in this area of experience, is not recommended. The dosage and adverse reactions of "children with medication" newborn infants and infants have not been determined, and this product is not recommended. "Elderly patients with medication" has not yet had experience in this area of medication. Care should be taken to observe the patient's condition and use caution.
Magnesium magnesium isoglycyrrhizinate with different Glycyrrhizic acid
