Http://www.asp.net/AJAX/Documentation/Live/BrowserCompatibilityForASPNETAJAX.aspx
Supported browsers
1) Microsoft Internet Explorer 6.0 or later versions.
2) Mozilla Firefox version 1.5 or later versions.
3) Opera version 9.0 or later versions.
4) Apple Safari version 2.0 or later versions.
Security and Privacy settings
The following table lists required browser security and privacy settings for both user browsing and site development. In all cases, the recommended settings are the default settings for that browser.
1) Internet Explorer 6
Make sure thatInternet ZoneIn the security zones settings is setMedium.
2) Internet Explorer 7
Make sure thatInternet ZoneIn the security zones settings is setMedium-high.
3) Firefox 1.5 or later versions
InToolsMenu underOptions, Make sure thatEnable JavascriptIs selected.
4) opera 9.0 or later versions
InToolsMenu underQuick preferences, Make sure thatEnable JavascriptIs selected.
5) Safari 2.0 or later versions
ClickSafari,Preferences,Security, And thenWeb ContentAnd make sure thatEnable JavascriptIs selected.