PyQt good, just be careful, this thing is GPL, if you want to write commercial program need to purchase license for commercial edition.
In addition PYGTK, Wxpython are good GUI library.
Python comes with a tkinter-based GUI library, which is the only option if you don't want to introduce third-party dependencies.
If you write programs under Mac, COCOA+PYOBJC is good too.
In addition, Java version of Python, Jython, can use Java GUI library such as awt/swing or SWT;.NET/CLI version of IronPython can be used. NET/CLI supported GUI libraries such as WinForm or WPF, This is also the best choice if you need to integrate Java or. NET functionality into your project.
Regardless of which GUI library you use, it is important to note that the GUI library has its own object architecture and lifetime management rules that are not necessarily identical to Python's own and require special attention.
Xu Chen
Links: http://www.zhihu.com/question/20533837/answer/15403596
Source: Know
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Python GUI Library