When you create an MQ queue manager, there are a few things to keep in mind:
1) The Queue Manager log type and the size and number of log files, according to the size of the user data, the total amount of messages on each queue, to calculate the total capacity of the log, in order to avoid the system in the process of running a log full of the situation;
2) A dead-letter queue should be specified and established for the Queue manager;
3) The maximum number of open handles Maxhands (the default is 256, if you need more than 256 applications to connect to the queue manager at the same time, you should increase the value), max message length MAXMSGL, maximum number of uncommitted messages Maxumsgs Property (default = 10000, If you are using message segmentation or grouping, the number of segments for a large message exceeds 10000, you should increase this value) for consideration.
MQ (creating MQ considerations)