Karyopherin
A group of proteins associated with the transfer molecule entering or exporting nuclei through a nuclear pore complex. It can be combined with the carrier and can be identified and combined by a nuclear pore protein to assist the carrying material through the nuclear hole.
Many proteins, ribosomal sub-units, or RNA, can pass through a nuclear pore under a transport factor mediator called the nuclear Transporter protein (Karyopherin). which can help the molecule into the nucleus of the also known as the internal transport protein (Importin), which helps the molecule to leave the nucleus is called the outer transport protein (exportin). Most nuclear transporter proteins can be directly associated with the molecules to be transported, while others require the transfer of protein to assist [9]. Steroid hormones such as cortisol and aldosterone, as well as other lipid-soluble molecules that act as cellular signals, can spread from cell membranes into the cytoplasm and bind to the nuclear receptor proteins that will enter the nucleus. [4] These receptors, when combined with ligand, have the function of transcription factors, and if the ligand does not exist, the receptor has the role of tissue-protein decarboxylase, which inhibits gene expression .
Nuclear transporter protein