1. See if there are any registrations in the handler mappings in IIS: extensionlessurlhandler-integrated-4.0
If not, you need to register in "run":aspnet_regiis.exe
2. Add <modules runallmanagedmodulesforallrequests= "true" in the configuration file/>
<system.webServer>
<validationvalidateintegratedmodeconfiguration= "false"/>
<modules runallmanagedmodulesforallrequests= "true"/>
</system.webServer>
Add <modules runallmanagedmodulesforallrequests= "true" in Web. config/>
If not, please check the "handler mapping", if there is "extensionlessurlhandler-integrated-4.0", if not, please register. net4.0
Input in operation:C:\Windows\Microsoft.NET\Framework\v4.0.30319\aspnet_regiis.exe-i
3.IIS application pool Integration mode, which identifies the user with the highest privileges to add in:
Configuration Issues for IIS 7
WEBAPI Publishing IIS Error issues