Audit < gene editing and precision Medical > (Peking University)

Yesterday, I went to Peking University for life sciences to listen to a lecture by Professor Wei Wensheng on genetics. The venue is not too many people, compared to the last time to listen to the city planning, the scene slightly deserted. It can also be reflected from one side, although there are not many people who are concerned with the basic science field.

Professor Wei used a propaganda poster as a guide, cancer can be overcome, HIV has a way to suppress it. At the moment, it's still not working.

From here he draws on the recent 30 years of research on the international dimension of genetics. Although the concept of gene editing has been around for thirty or forty years, there have been some groundbreaking research results in the last two years, and it is very gratifying.

He mentioned that the precise medical plan (http://www.biomart.cn/news/103/106/146434.htm,http://www.bioon.com/3g/id/6667612/) proposed by Barack Obama last year At the Obama conference, he invited a girl with cancer to share. The girl was fortunate that her father was a professor of genetics, because her cancer had no genetic material at the moment, so the professor openly recruited the people of the United States to get the disease, then analyzed their genes, and finally targeted the cancer's genetic characteristics, successfully cured his daughter. This is a matter of deep thought, the United States has begun to try such high-end areas, and China is still for the death of Wei Zesi, indignant. However, it is worth saying that Professor Wei's laboratory in this area has also begun to obtain some research results, but also published in Nature magazine several papers. I hope that China in this wave of technological development can keep up with the pace, but also to Professor Wei, such researchers to pay the highest respect.

After that, he introduced the two main points that need to be tackled in gene precision medicine.
1. Gene Mapping
2. Post-positioning drug development
The localization of genes is the most critical part.
At present, the major gene editing is the double strand fracture of DNA, then the gene replacement or repair. At present, the main use of gene self-healing ability to carry out late gene accurate editing. and gene self-repair is divided into two kinds
1. More rough, the fracture is directly mixed, but this will lose the genetic information
2. Accurate repair, by reference to other DNA, for very accurate repair, the shortcomings of repair slow

Gene mapping has now developed three technologies
1.ZFP comparison Early
2.TALEN
3. CRISPR's most revolutionary

Finally, he introduced some of the results of their labs, mainly the screening of high-throughput genes.

Finally, a picture of the classic principle of CRISPR

Finally, he mentions the issue of genetic ethics, and I also get a chance to ask questions about the ethical risks of the future of human genetics. His answer is that this is a big trend, and the bottom line in world science is that germ cells are not allowed, (though Japan has passed the bill), but progress has been getting faster in recent years. Some scientists are very worried, and very pessimistic, that this will lead to the rapid extinction of human beings, but some people think that human can do self-restraint, to avoid serious consequences. Finally, he said, in the end it is a philosophical question, where the human race should go.

The end is a bit heavy, but still want to believe in a better future, but also believe that gene precision treatment can be human to overcome cancer, AIDS contribute.

As a programmer, we had better resources to contact foreign advanced ideas, technology, do not self-closed, but also not only focus on the computer, open horizons, to contact with what they want to contact. Share.

Audit < gene editing and precision Medical > (Peking University)