HBV (16) _ liver-preserving drugs

Directory:

1. Glycyrrhizic acid diamine

2. Matrine (Oxymatrine)

1. Glycyrrhizic acid diamine

Diammonium glycyrrhizinate for injection, molecular formula: c42h62o16.2h3n relative molecular weight 856.997cas 79165-06-3Pharmacological Toxicology:This product is the third-generation extract of the active ingredient of licorice, which has certain anti-inflammatory, protective liver cell membrane and the function of improving liver function. Pharmacological experiments show that the oral administration of mice can alleviate the increase of serum alanine aminotransferase (ALT) and aspartic acid aminotransferase (AST) caused by carbon tetrachloride, acetyl amine and D-amino half lactic acid. It can also significantly reduce the damage of D-amino-lactic acid to liver and improve the chronic injury of immune factor to liver.Indications:This product is suitable for acute and chronic viral hepatitis with elevated alanine aminotransferase (ALT).Adverse Reactions:1. Digestive system: Can appear the difference, nausea, vomiting, bloating. 2. Cardio-cerebrovascular system: headache, dizziness, chest tightness, palpitation, and increased blood pressure can occur. 3. Other: Itchy skin, urticaria, dry mouth and swelling. The above symptoms are generally mild and do not affect treatment.Taboo(1). Severe hypokalemia, hyponatremia, high blood pressure, heart failure, kidney failure patients are disabled. (2). This product is not diluted without being injected. (3). In the course of treatment, blood pressure, serum potassium and sodium concentrations should be detected regularly, such as hypertension, sodium retention, low blood potassium, etc. should be discontinued or appropriate reduction. (4) Pregnant women, newborns, infants and children dose and adverse reactions have not been established, temporary use.2. Matrine (oxymatrine)Oxymatrine/marineIndications:Chronic hepatitis BAdverse Reactions:fever accompanied by fatigue, poor, nausea, headacheMedication Tabooprohibit use of other antiviral drugs during medicationMatrine (oxymatrine) is a Chinese scholar from bitter beans extracted from traditional Chinese medicine, has been made into intravenous and intramuscular injections and oral preparations. Clinical studies in China show that this contraceptive has improved the liver biochemistry index and certain anti-HBV effect [82-84]. However, the exact effect of anti-HBV is still needed to enlarge the number of cases, and the rigorous multi-center randomized controlled clinical trials were validated.

Traditional Chinese medicine treatment of chronic hepatitis B is widely used in China, but most of the drug lack of strict randomized controlled study, the antiviral effect still need to be further verified.

HBV (16) _ liver-preserving drugs