2015 China (Shenzhen) It leaders Summit today Wuzhou Hotel held

Absrtact: March 22, 2015 China (Shenzhen) It leaders Summit today Wuzhou Hotel held. Wang, chief executive of the Chinese gene, described in his speech the relationship between the brain and the brain, and the genetic science behind it. The following is the full text of Wang speech: Thank you, Mayor.

March 22, 2015 China (Shenzhen) It leaders Summit today Wuzhou Hotel held. Wang, chief executive of the Chinese gene, described in his speech the relationship between the brain and the brain, and the genetic science behind it.

The following is the full text of Wang speech:

Thank you, mayor, today I am addressing the topic called "it and BT Fusion industry," The issue is not my choice of topic, I chose the topic was called "The Language of Life", but was finally the organizing committee. I'm a gene-tech guy. Run to the IT leaders Summit, so I have to have some topics to reflect it, so I changed a topic when BT met it who would fall in love with it. Later, my assistant told me not to use this topic, will be called back, and then I thought of a will not be called back to the topic. Although the topic sounds prosaic, it must be approved. I am more stubborn, so I would like to talk about the language of life, why use the language of life to explain today's topic?

When we talk about digitalization, talk about computers, talk about it, and get used to silicon as a system. But when it comes to life, carbon is the system. Life is based on carbon, life is digital, why is life digital? Can it be stored? Can you program? Can different programs change to achieve different life forms? Can I do a clone? Yes or no? Of course it's OK, we're easy to clone. Can it be stored? Can, why so simple to mention a cell from a sheep to become another sheep? Because the sheep's cells store all the sheep's life program. How many years can a large-slap DNA be stored? In fact, the storage time of billions of years can be achieved, at least for millions of years. No storage medium can store such information carriers for millions of years, so DNA can be stored. Can he calculate? Of course I can. Because the core unit of computing and programming is genes, genes are the most basic constituent units of life. Each of us contains a combination of information is a basic set of life information program, this basic program is the language of life. How does its language form? At the very beginning, it's like every programmer writes out a functional module and wants everyone to use his module, there are genes, proteins, small molecules, genes, proteins, and small molecules in the body of life that want to expand and expand and, in fact, have a very famous book in the United States. The whole process is constantly replicating, expanding, expanding, and sometimes finding that a gene is not enough to work with other genes, two genes, three genes to work together better, and when a bunch of genes collaborate better, an individual is formed. We have 230,000 genes, rice has more than 50,000 genes, different species have different genes, for example, we now see a yeast with 4,000 genes, all different gene combinations in different forms of life program, different life program to form your individual and the surrounding environment adapt. Each of your programs represents a different survival strategy, and the different survival strategies are actually directed at different environmental systems. The only standard that he can use to check your program is whether or not your program will survive and spread more offspring. This program, when you choose to spread more offspring, is called the life language that can be adapted to this set of circumstances. So we see the so-called Darwinian evolution theory, the survival of the fittest is built on this foundation, each of us more genetic information vector, everyone and the micro-worms have found similarities, a lot of genes from there to us.

The

is the same for individuals, and everyone has a different set of life procedures. Why the Tibetan people can adapt to the mountains, why we have a very strong plateau response, because the body set of procedures did not write into the mountain adaptation of the gene, Tibetans have a gene, there is the gene of the population can be in the plateau system no response, as we are not on the top. In the Han Chinese system, only 5% people have this gene, while Tibetans reach 95%. Such things are not only in Tibet's particularly complex and extreme environment, there are many things related to diet, such as the southern Dai people because of their ancestors often eat betel nut, so the body of many genes with betel nut adaptation. Wait a minute. I can give a lot of examples. This is the change of individual level. Why do individual levels change? Why Tibetan people are different from Han Chinese? What's going on with its branches? In fact, he has a lot of interesting things behind. For example, what is its source of change? When we consider a combination of sperm and eggs, he has a reorganization, in each generation, your child and parents have 100 mutations in the gene, which form a different survival strategy, the environment at all times change, the gene changes constantly, the genome is the predictive process. Your genes are the result of the thousands of years and thousands of years of your ancestors learning, evolving, and predicting the circumstances you might encounter later. Your genes will not tell you to go to the plateau, but will tell you what happens when you finish the plateau. This is a very interesting assumption. If everyone was born with a box, the box clearly tells you where to go and what happens, how does he guide and live with us? First of all, if I have a box, programming tells me how old I can live. Some people say that your genes, if you do a really good job of following genes to tell you things, you can live to 150 years old, but why not live to 150 years old? Because you are going to get all kinds of diseases, which have to do with the relationship between young and old, and what is the relationship between these diseases and genetics, or with the environment, with digitization, with it, BT? I explained it in several ways.

The bugs in the genes are a bit like a bug in a program, a bug, a genetic program that doesn't run, and sometimes a very serious problem. such as all kinds of rare diseases. The general survival cycle of rare diseases is very short, we have a variety of examples, this rare disease sounds very rare, but it is not rare to add up, more than 5.6% of the children born in China have a variety of birth defects, very large. Life program constantly try the code, trial code process of trial and error, of course, each error does not represent the possibility of new forward evolution. What are we going to do with them? Wah da often received such things, this is a blood, from a scale disease patients to us, they have an organization, such as the Association of porcelain Dolls, etc., the wife of this fish scale disease wrote, he hopes to be able to turn this disease to be controllable. Now the lady had a child, luckily she had not got the disease. It's because of the genetic testing of this program. When the child is born, I can do some testing, early found that there are any problems, early control, of course. This is the first. Can I check if your father or mother has genetic mutation, if so, how many chances you have children, if so, then do not match the eight-story, love before marriage with a gene to see the life gene program is not matching. We generally swear in the church that, whether it is disease or not, health is a generation to stay together. In Fujian, Guangdong province, the incidence of thalassemia is almost 19%, if there are two carriers of the combination of couples, the possibility of a high school anemia child is very high. We can artificially fertilize, do a pre transplant test, before transplant test in China many hospitals have already carried out. Another step, what if pregnant? Complete genetic testing of children can be performed within pregnancy months, especially for very rare genetic diseases, which can be achieved through prenatal control. If you go down again, will the newborn be born without testing? The incidence of deafness in China is due to the wrong use of antibiotics, if the body gene can not be affected by streptomycin this antibiotic, then deafness. Would we have intervened earlier if I had known that he had a wide range of heart disease, deafness, including autism risk? is OK. Can we cure it? In addition to looking at these things with a very variable message, we have a very crazy idea, can we find some real solutions to rare diseases through large data mining? The answer is yes, very interesting, we have a plan to search 1 million of people genetic data, looking for those who simply from the genetic proof that he should be a single gene disease, but very healthy, these people we call superheroes, these people are very interesting, they have a very specific disease-causing genes, but very healthy, why? Because the body has another set of genes to protect him. Like the program I have a bug, but there is another section of repair, very healthy. If you find out what that paragraph is, maybeDrugs to identify rare diseases. We are not going to pour the ice bucket again, this is moral support, and more important support is genetic sequencing.

Further down is a tumor, many people face the tumor threat, the tumor is your survival process due to environmental factors, your genetic procedures in the mutation, all cells from the first cell, fertilized egg cells, from the beginning of the cell every time the program changes. Different environmental effects can lead to very different programs, such as smoking increases the rate of lung cell variability. In simple it way, it is your life program that code is hacked to black. Hacker black probability will vary with environmental factors, if often smoking, if often live in bad environment, Shenzhen is very good. Or infected by a variety of viruses, the program may be hacked. What do we do? It is possible that a cell has been black, it does not matter, some people say that I have billions of cells in the body. But if a cell is hacked, he is likely to gain more adaptability than any other cell, and he can continue to expand. From a tumor cell to your end you can use a CT scan to find out, on average, 15 years. That is, there are tumor cells in the body in the 15. You don't know if we can find him early, the answer is yes, because all the cells end up in the bloodstream, and we can see through a very deep genetic test that there are no tumor cells in your body.

What if I got a tumor? Each person's tumor, every individual, tumor, every cell has a different gene, and what you do is to monitor all of the cell's true genes, rather than simply surgery, radiotherapy, chemotherapy, which is likely to see rapid development over the next two or three years. If all efforts are to increase the survival probability of cancer patients, there are other things that I have not mentioned, but people are very concerned about, for example, chronic diseases, infectious diseases, in fact, everything is related to genes. My body cells if the human body as a whole, as a person this individual cells accounted for only 1/10 of human cells, and 9/10 is a variety of microorganisms, a variety of viruses, you wash two times a day without the use of bath. You absorb 1.5 hours and all the germs are back. Not all of these microbes are bad, like what happens to microbes in microorganisms? The impact is very large, such as Ebola virus, SARS virus, 90% fever diarrhea You have no idea what's going on. Less than 1% microbes can be cultured, and you have no way of figuring out what's keeping you from getting a fever or diarrhea, and you can extract all your DNA and know how it can be infected within one hours. If you do this earlier, you can get rid of the risk of disease earlier.

There is another thing, hyperglycemia, high blood pressure three high, 30 years ago, the incidence of diabetes mellitus in China 0.67%, now close to 11%,1/4 Chinese adults either have diabetes, or get diabetes, it is not possible that the gene in the past 30 years has been a very big change, because of dietary changes, environmental changes, Cause intestinal microbial flora disorders, many diseases are related to this. What can you do? For example, eat less carbohydrates, such as more exercise, and then a little more fierce, after the check, the lack of any micro-organisms to fill what. If you make up one or two of them, it's OK to transfer the microbes you think are healthy to you. Manure transplants, such things have gradually been applied in the medical world. What we should do is a cocktail therapy, make sure that your body is in line with a truly healthy flora, and that eventually we have to complete this life formula, our genes, the environmental factors, all sorts of things, the right side is your performance, height, weight, various pathological features, health or not, how to write the middle formula? This time reflects a just Wunda teacher talk about the topic, we only know a city's input, output, the middle is how to program, there is no known. What should I do? Large data, large health data depends on all the input and output of the calculation clearly, if the study of the relationship between the height of genes, need 1 million people. It takes 1 million people to study the relationship between the vast majority of complex diseases and genes and the environment. You need to collect all kinds of information about 1 million people to get the life formula you just told.

In what way? Is this method expensive? This method is very expensive. 1999 China Huada Gene participated in the 1% Human Genome Project. At that time, the sequencing required 1 billion U.S. dollars, recently reduced to 10,000 U.S. dollars, still very expensive, to collect 1 million people's data is still very expensive, now can do 1000 dollars, I think next year will introduce a 500 U.S. dollars can determine a person's complete gene. This allows the collection of genetic data. When can it be free? The advent of free implementation is, in fact, that the data value of the gene itself is far greater than the cost of generating his data. For China's big talk such a trend continues we think that in 2019 years or so, 5 years or so time we can really achieve this result. In addition to this genetic data, we know that now the more fashionable word, the internet of Things, the collection of various input and output data, such as the future toilet will be a smart toilet, when convenient in the toilet, all metabolites, protein data and so on data are collected, including lying on the bed of various physical signs data Car and so on all kinds of data are collected, you must remember to connect them, why the genome network so important, all the people here, all the men 120,000 years ago from a man, all women 120,000 years ago from a woman. What is the concept that our scientific research finds that all come from one person? Some people say that this is Adam and Eve, 70% Han Chinese people in China dating back to 6,000 years ago three people, inflammatory Huang Yuyu. All East Asians, 40% of East Asians, date back to 11 people. If you connect everyone's data to form a genome network, it will be immeasurable, we talk about the Internet. It Internet companies, supercomputers, personal computers, are truly an invaluable opportunity. Each person generates data and support on it, and the genome is the same. The Human Genome project, everyone's genetic program, when all genomes form networks, we have a website called the Freemasonry site, and when all patients combine a site, we may have the opportunity to make clear the relationship between the gene and the disease, which will create a variety of opportunities, The information and knowledge that we had before in not doing even a personal genome was unthinkable. The ultimate thing to do is to need artificial intelligence to learn, because such a large amount is no longer possible to use a single model to solve. And Hua Da is already doing a lot of things, these things sound like Arabian Nights, we made 3000 strains of millet, in the same place to determine the various growth conditions, and finally see how much he produced, nutrition, a variety of results, we give him in-depth study, artificial intelligence methods, now given another in the millet, I have 90% accuracy to predict how he looks. Do you have the ability to be healthy? When we had the genetic sequencing of 1 million people, we were close to this ability. Obama proposed an accurate medical plan to do 1 million people genome Library, when everyone is finished, we will have a crystal ball, forecast for your future health to predict, and such a preIt's possible to make a few more changes, we've heard of 3D print, cell storage, gene editing, we've heard of synthetic biology, the yeast for drinking beer will not be natural yeast, it's written by the computer, and the yeast-generated beer may taste better than any beer you drink now. Also, the storage of life information, we are called stem cells, stem cells what do you mean? Is Young life information, you do not want to be young? In your old age, if you can return the message of your youth, you may be young. All things like scientific fantasies are moving forward in a fast way in the life sciences. From a health standpoint, we always say we eat well and live long. The pursuit of health is not a sensual desire, it's more important for us to be a rational pursuit for the big it guys here, if it's really the most meaningful way to manage health, to master predictive procedures and health relationships based on a so-called artificial intelligence approach, which is probably the most rewarding thing that gene technology can bring to human well-being, Natural beauty for the United States, people to health and longevity, all of China should pursue the goal is genetic technology for the benefit of mankind. If you simply say Huada, Hua da is the world's largest genome center, the largest biological information center. There are only 5500 people, our average age is 27 years old. China large institutions in more than 60 countries, at the same time is the national gene pool contractor, the national gene pool storage of various life information body.

When we define a life, in fact, we can not say clearly, if in the future computer system to give him a lot of life logic, he will become a living body? If we calculate that the brain can match the human brain, does it have life? How are we supposed to control our ability when we have a human gene change? All these things are worth thinking about, as another latitude of it people, everyone here is the silicon gene dimension, I am the carbon gene dimension, as the other latitude, I hope to bring you not only the cognition of life, but also the best rational choice for health cognition. Thank you!